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Abstract Minimally invasive endovascular therapy (MIET) is an innovative technique that utilizes percutaneous access and transcatheter implantation of medical devices to treat vascular diseases. However, conventional devices often face limitations such as incomplete or suboptimal treatment, leading to issues like recanalization in brain aneurysms, endoleaks in aortic aneurysms, and paravalvular leaks in cardiac valves. In this study, we introduce a new metastructure design for MIET employing re-entrant honeycomb structures with negative Poisson’s ratio (NPR), which are initially designed through topology optimization and subsequently mapped onto a cylindrical surface. Using ferromagnetic soft materials, we developed structures with adjustable mechanical properties called magnetically activated structures (MAS). These magnetically activated structures can change shape under noninvasive magnetic fields, letting them fit against blood vessel walls to fix leaks or movement issues. The soft ferromagnetic materials allow the stent design to be remotely controlled, changed, and rearranged using external magnetic fields. This offers accurate control over stent placement and positioning inside blood vessels. We performed magneto-mechanical simulations to evaluate the proposed design’s performance. Experimental tests were conducted on prototype beams to assess their bending and torsional responses to external magnetic fields. The simulation results were compared with experimental data to determine the accuracy of the magneto-mechanical simulation model for ferromagnetic soft materials. After validating the model, it was used to analyze the deformation behavior of the plane matrix and cylindrical structure designs of the Negative Poisson’s Ratio (NPR) metamaterial. The results indicate that the plane matrix NPR metamaterial design exhibits concurrent vertical and horizontal expansion when subjected to an external magnetic field. In contrast, the cylindrical structure demonstrates simultaneous axial and radial expansion under the same conditions. The preliminary findings demonstrate the considerable potential and practicality of the proposed methodology in the development of magnetically activated MIET devices, which offer biocompatibility, a diminished risk of adverse reactions, and enhanced therapeutic outcomes. Integrating ferromagnetic soft materials into mechanical metastructures unlocks promising opportunities for designing stents with adjustable mechanical properties, propelling the field towards more sophisticated minimally invasive vascular interventions.